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Health update 2

Here's the plan:

  1. Put me back on high-flow oxygen.
  2. Slam me with IV steroids. Quadruple the dose and administer every six hours.
  3. If that doesn't work, slam me with antibiotics.
  4. If that doesn't work, intubate me and do a broncoscopy.

There are further options after that, but not good ones. Bottom line: doctors just don't know what's going on and are worried about secondary infections.

30 thoughts on “Health update 2

    1. Jimm

      https://www.jstage.jst.go.jp/article/jos/71/8/71_ess22008/_article/-char/en

      "The docking experiment showed that all compounds could directly interact with CRP. Oleuropein had the most potent interaction with CRP (-7.7580), followed by indomethacin (-6.0775), oleocanthal (-5.5734), ibuprofen (-5.3857), phosphocholine (-4.3876), HT (-4.2782), and tyrosol (-4.2329). Interestingly, the present study found other phytochemicals in olive oil that can be exploited as potential, safe, and cost-effective lead compound(s) for analgesic and anti-inflammatory activity, as supported by its molecular docking data."

    2. Jimm

      https://www.sciencedirect.com/science/article/pii/S155083072200204X. (olive leaf extract)

      "Of the 150 patients randomized into groups, 141 completed the follow-up and were analyzed. On the fifth day of hospitalization, body temperature (MD=0.34, P<0.001), pulse rate (MD=5.42, P=0.016), respiratory rate (MD=1.66, P=0.001), ESR (MD=13.55, P<0.001), and CRP (MD=15.68, P<0.001) of intervention A were significantly lower than the control group, while oxygen saturation (MD= -1.81, P=0.001) of intervention A was significantly higher than the control group.

      Furthermore, body temperature (MD=0.30, P=0.001), pulse rate (MD=5.29, P=0.022), respiratory rate (MD=1.41, P=0.006), ESR (MD=14.79, P<0.001), and CRP (MD=16.28, P<0.001) of intervention B were significantly lower than the control group, while oxygen saturation (MD= -2.38, P<0.001) of intervention B was significantly higher than the control group."

  1. Jimm

    The important thing is determining why the inflammation is growing, your body is obviously fighting something. It's not a direct analogy to fever, but generally a fever is a natural phenomenon that means your immune system is working, and there's no need to bring it down just keep it at a safe level (which usually is self-regulatory). This spike in inflammation different than that obviously and concerning, because potentially more a measure of damage and goal is almost always to being inflammation down.

    If double pneumonia I'm sure they're focused on it, obviously don't want you to become septic. This is where I kind of get frustrated with the state of our current medicine, we know by a lot of evidence now that natural substances and foods like turmeric and certain medicinal mushrooms would be helpful to your condition right now, but always overthink that these may interfere with prescribed medicines, when most studies so far show they don't (the most credible concern I've seen in some cases is looking out for natural compounds that thin the blood, if already on blood thinners, even though reducing the prescribed blood thinner in those cases would seem to make sense if we truly believe the natural foods will do the same, and with additional synergistic benefits).

  2. Anonymous At Work

    Hopefully your kidneys will hold up. This is a pretty harsh rollercoaster for several major organs as the doctors are trying to fry a bacterial infection that's resisting normal course of treatment in an immunocompromised individual. The good news is that your CAR-T treatment gives them a lot of health data on you and your tolerances. Bad news is that "Fuck Cancer" is always putting it mildly since it's a nasty disease that can leave people with few options.
    Good luck.

  3. golack

    We love your blogging, but do take care of yourself.
    Granted, blogging might be a welcome distraction for you when you can focus.

  4. mistermeyer

    Disclaimer: My medical training consists of many episodes of ER, House, and Scrubs. That said... Remember the warning about a cytokine storm? Yeah. That. You get inflammation of the everything, and the medical folks tend to pay attention to all the individual effects, of which there are many. Happened to my wife; took forever to diagnose and fix. Anyway, my money is on the steroid treatment. (This is what happened to a lot of Lupus patients when their supply of hydroxychloroquine dried up, thanks to COVID cranks.)

  5. CAbornandbred

    Hang in the Kevin. I'm pulling for you, which, along with the other Kevin readers here is one heck of a lot of pulling. Hang on to the bed.

  6. seawaze67

    Hang in there - anything lung related always seems slow to heal - be it a cough or an actual infection. Should clear up with time, rest, and plenty of drugs.

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