I'm not quite sure what to make of this, but . . .
My M-protein number is continuing to drop. It's now at 0.21, quite a bit less than it was a couple of weeks ago.
Will it keep dropping? Was my response to the CAR-T better than I thought? Is it an unusual response that takes a long time to bottom out? Will it eventually hit zero?
My doctor doesn't know and neither do I. That said, lower is always better. At the very least, it suggests I'll have a longer period of low cancer load before I have to start up another round of chemotherapy. So it's good news.
I don't know either, obviously, but I do know that everybody's system reacts differently to things, sometimes by a little, sometimes by a lot. Here's hoping that trendline meets its axis!
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Lower is always better -- that's my philosophy in most things except income.
Were you asked to keep a daily diary -- dietary or lifestyle changes?
Very glad to see this update, & hope that your results continue to be better.
Because Science! Which we do not as yet fully understand.
I'd been wondering if the CAR-T treatment was too specific and the cancer had too much various DNA to completely target.
Allowing a margin for error (especially for the 0.34 data point), perhaps an exponential is a better predictor. It never reaches zero but does keep getting better, which is what's most important.
Looking through a few of the m-protein updates of the recentish past, the conclusion I draw is one should not try to fit trendiness to the results and extrapolate.
Yep. I am experiencing a similarly lazy trend line from Abecma received in December of 2022. Light are perfect, M-spike ambivalent. Wishing you continued improvement.
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Great news Kevin. You're right, lower is better. Here's hoping the next result is even lower. In the words of the great Chubby Checker, "How low can you go?"
It is! Enjoy!
Looks great!
it just means you have been taking my prescription of large doses of cat interactions. More cat, more health. Maybe add a booster kitten, just to play it safe.
That's great--I hope the trend continues.
Well, this certainly seems like good news. In any case, it's not bad news, so that's good! I think it's because you've go so many people pulling for you. Here's to continued not bad news!
Sometimes the answer is a broken (powerlaw, line, whatever). My own alpha fetoproteins, many decades ago, gave me quite the scare as they beautifully followed one powerlaw decay after surgery, only to have clear break to a shallower decay, which thankfully continued their decay, albeit at a slower trend.
Here's hoping you've got a similar break, but not overall change in the trend.
We saw a similar break when monitoring the powerlaw mass increase of our baby ducks. First two weeks was scary, but thankfully broke, and then stopped, as evidenced by the fact that the Universe did not collapse in on itself after a year and a half. (It literally was that kind of growth rate for the first two weeks.)
Crossing fingers for a line-break-line fit being the right answer.
Super News, KD! Let's hope for a trend.
Yahoo! This is great news, I think. Maybe your response is just a little delayed. We are pulling for ya Kevin.
At the start of the year my AST / ALT were nearly double my normal levels. I wound up in the hospital, 5 months later, unrelated issue, and they were normal.
Even when medicine works, it can be in mysterious ways.
This is great news, Kevin!
I recall reading somewhere that about half of CAR-T patients who have a partial response at 3 months eventually have a total response after a year.
Many, many years of cat photos! Hooray!