This is neither here nor there, just something that's been bugging me for a while. It's a timeline of vaccine development after the pandemic hit in 2020:
I've got no beef with Operation Warp Speed, which set up a pretty effective program to handle expedited development and manufacturing of COVID vaccines. That said, virtually everything of importance regarding vaccine development happened before Warp Speed was announced, and it was funded by grants from Congress, not Donald Trump. "Warp speed" was an effective marketing slogan, but beyond that it mostly just picked up a ball that was already in play.
Donald Trump, and Donald Trump alone, saved the world from COVID.
Except COVID was a hoax, just an excuse to inject people with microchips
And vaccines cause autism and infect you with diseases. And natural immunity is better anyway.
Also something something Big Pharma something lockdown something Marxist Fascist mind control something.
In conclusion, only Donald Trump can save us, the end.
I couldn't have said it better myself. All hail Trump. 🤮🤮
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I think "Eve" has gone bonkers. From AI to random word salad. Can no one rid us of this troublesome 'bot??
That vaccine would have taken 10 years without Trump!
(Or whatever number he finally got up to ... it seemed to keep increasing. I'm reminded of Daniel Dale's term "lieflation.")
On balance -- and granted, it's easy to say because in reality it never came this -- I would have been OK if Trump had claimed unearned credit for the vaccine ( "the best vaccine ever!") and urged all of his followers to join the rest of us and go get "the Trump vaccine". We would have a lot more of our fellow citizens still alive, and a lot lower level of continuing spread of the virus, which remains a threat to us all.
If memory serves me right he actually tried this briefly, but when he saw the reaction from his fans was uniformly negative, he just pretended he never said that, and carried on without again encouraging them to get vaccinated with "his" vaccine.
That's my memory, too. A more nuanced version of my point is that for once I wish that one of his self-aggrandizements had worked.
Operation Warp Speed did more than you're highlighting.
- OWS funded the purchase of the hundreds of millions of doses and purchased hundreds of millions of syringes and vials.
- They funded 2 other vaccine-makers than what you highlighted.
- It allowed the EUA for vaccines even while testing continued.
- It allowed the overlapping of non-sequential phases to compress the approval timeline by years. Moderna was running all three phases just months after OWS started.
In fairness yes, they threw a lot of money at a lot of useful parts of the implementation phase (as opposed to the development phase), and they did a lot to streamline various bureaucratic processes.
Whether in the end that compensated for the outright lunacy that permeated the administration, starting at the very top with Mr Inject-The-Bleach and Bring-The-Light-Inside, along with all the other active and tacit sabotage of public health measures, is an open question. (My guess is not.)
This is a case in which Trump really (really!!) wanted to claim credit for the vaccine but his “followers” forced him down another path. His crazies decided they didn’t want the vaccine because (various conspiracies) and he had no choice except to follow their wishes. He was even booed by his supporters when he told them he had gotten the booster:
https://www.cnn.com/2021/12/20/politics/donald-trump-booster-shot-boos/index.html
It truly is weird.
DJT lied, details at 11!
Anchor: Oh fork it, I need something new!
This beef is dry and cool...
I’m just disappointed that Covid didn’t kill trump. So close!
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Interesting...If a Democratic President was in office and tried this, all we'd be hearing now was how this was just like Solendra! Look at all those vaccines that didn't work!! Congress has to INVESTIGATE!!!
Warp speed did a bit more than you gave it credit for. Granted, Pfizer/BioNTech did take (direct) funding from Operation Warp Speed, but the purchase agreements, setting up of a cold chain for vaccine distribution, etc., all helped too.
Here's the thing--these vaccines were also built on the shoulders of many decades of biomedical research. There was luck involved too--but funding went to different manufacturers trying different things and we ran with what worked. And we learned a lot too about how different types of vaccines work, and were able to see side effects that were very rare. That means we should be better at making vaccines.
I have no problem with Trump claiming credit for OWS, but let's face it, anyone with the brains that God gave broccoli would have done the same.
Wasn’t it a German Turkish couple (Sahin and Tureci) that revolutionized RNA vaccine technology? Like all great discovery and inventions, there are probably hundreds of anonymous contributors and of course government funding from various sources and countries aided in the effort. The reason Trump was given credit for Warp Speed was to gratify his ego so he would not get in the way. It’s telling how many times this has happened.
But Marginal Revolution links to a Mathew Tabarrok piece on how NSF was faster than NIH? https://progress.institute/how-the-nsf-moved-faster-than-the-nih/
I wonder about the nitty details--when did money actually hit the bank accounts of scientists or companies; is that really the key factor or is it the approval on paper which means the "check is in the mail"; or is it really a bunch of people in and out of govt see the signs and start working their asses off in the best way they know how, with some reasonable confidence that the work is worth doing for society, and maybe the effort will be compensated/rewarded?
While we can tinker with the bureaucratic rules, the real strength of America is the freedom and flexibility to do so.
I'm not sure you've taken into account exactly how hard and expensive Phase 2 and, especially, Phase 3 trials are. Phase 1 & 2 were finished over the summer and involved relatively small test groups, Phase 1 for safety and Phase 2 to get a sense of the dose to use for Phase 3. There were 70,000 Phase 3 participants in the Pfizer and Moderna trials. Producing a first batch in January or February was nothing like what was needed for Phase 3. Production had to be scaled to produce tens of thousands of vaccines all the while with supply lines disrupted and limited suppliers since the entire vaccine technology was new.
Since you want the best possible data from you insanely expensive Phase 3, the phase that actually tells you whether you have a vaccine or a vaccine candidate, you want to manufacture one huge batch. There are consulting companies that specialize in figuring out how big a batch of a drug one needs to run a Phase 3 trial. Not every pharma house has the necessary expertise. If you have to manufacture a second batch to complete the trial, you may get degraded data. Honest, there is so much damned noise in the process and the whole thing is so expensive, that every bit of signal is hard won.
When the Cystic Fibrosis Foundation supported the development of Kayledeco, the first CF drug, they sold the future cash flow stream for the inhaled antibiotic they had funded earlier and raised over $100M. They spend that to figure out how to manufacture the drug at scale in parallel with the Phase 1 & 2 trials. That was $100M just to figure out how to manufacture the drug, and they paid even before they knew that the drug worked and didn't have showstopper side effects.
Manufacturing drugs can be surprisingly difficult. There was a recent paper on Paxlovid discussing its chemistry and manufacture. The usual FDA rule is that every ingredient needs at least two reliable suppliers. For Paxlovid, they went with seven, and they developed alternate synthesis pathways so that they could continue to produce the drug in the face of disruptions.
Now, you can argue that Warp Speed was unnecessary. Pfizer didn't want the government involved, but overlapping testing while solving manufacturing problems can be expensive, and even more so if the drug doesn't work. Having some extra money in the pot may have made a difference.